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Target
NAD-dependent protein deacetylase sirtuin-7
Ligand
BDBM50518646
Substrate
n/a
Meas. Tech.
ChEMBL_1872128 (CHEMBL4373295)
IC50
85300±n/a nM
Citation
 Li, S; Wu, B; Zheng, W Cyclic tripeptide-based potent human SIRT7 inhibitors. Bioorg Med Chem Lett 29:461-465 (2019) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-7
Synonyms:
NAD-dependent protein deacetylase sirtuin-7 (SIRT7) | SIR2L7 | SIR7_HUMAN | SIRT7
Type:
Protein
Mol. Mass.:
44925.61
Organism:
Homo sapiens (Human)
Description:
Q9NRC8
Residue:
400
Sequence:
MAAGGLSRSERKAAERVRRLREEQQRERLRQVSRILRKAAAERSAEEGRLLAESADLVTELQGRSRRREGLKRRQEEVCDDPEELRGKVRELASAVRNAKYLVVYTGAGISTAASIPDYRGPNGVWTLLQKGRSVSAADLSEAEPTLTHMSITRLHEQKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVCTSCVPNREYVRVFDVTERTALHRHQTGRTCHKCGTQLRDTIVHFGERGTLGQPLNWEAATEAASRADTILCLGSSLKVLKKYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVMRLLMAELGLEIPAYSRWQDPIFSLATPLRAGEEGSHSRKSLCRSREEAPPGDRGAPLSSAPILGGWFGRGCTKRTKRKKVT
  
Inhibitor
Name:
BDBM50518646
Synonyms:
CHEMBL4522166
Type:
Small organic molecule
Emp. Form.:
C41H76N12O7S
Mol. Mass.:
881.183
SMILES:
CCCCCCCCCCCCCCNC(=S)NCCCC[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)CCC(=O)NCC(=O)NCCCC[C@H](NC1=O)C(N)=O |r|
Structure:
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