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Target
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Ligand
BDBM50518734
Substrate
n/a
Meas. Tech.
ChEMBL_1872186 (CHEMBL4373353)
Ki
1370±n/a nM
Citation
 Ieda, N; Itoh, K; Inoue, Y; Izumiya, Y; Kawaguchi, M; Miyata, N; Nakagawa, H An irreversible inhibitor of peptidyl-prolyl cis/trans isomerase Pin1 and evaluation of cytotoxicity. Bioorg Med Chem Lett 29:353-356 (2019) [PubMed]  Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Synonyms:
PIN1 | PIN1_HUMAN | PPIase Pin1 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Type:
PROTEIN
Mol. Mass.:
18248.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1502595
Residue:
163
Sequence:
MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE
  
Inhibitor
Name:
BDBM50518734
Synonyms:
CHEMBL4467081
Type:
Small organic molecule
Emp. Form.:
C22H24N2O5
Mol. Mass.:
396.4364
SMILES:
OC(=O)[C@H](CCC(=O)N1CCOCC1)NC(=O)\C=C\c1ccc2ccccc2c1 |r|
Structure:
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