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Target
GMP synthase [glutamine-hydrolyzing]
Ligand
BDBM50519498
Substrate
n/a
Meas. Tech.
ChEMBL_1875728 (CHEMBL4377122)
IC50
46500±n/a nM
Citation
 Cheviet, T; Lefebvre-Tournier, I; Wein, S; Peyrottes, S Plasmodium Purine Metabolism and Its Inhibition by Nucleoside and Nucleotide Analogues. J Med Chem 62:8365-8391 (2019) [PubMed]  Article 
Target
Name:
GMP synthase [glutamine-hydrolyzing]
Synonyms:
6.3.5.2 | GMP synthase [glutamine-hydrolyzing] | GMP synthetase | GMPS | GUAA_HUMAN | Glutamine amidotransferase
Type:
PROTEIN
Mol. Mass.:
76718.04
Organism:
Homo sapiens
Description:
ChEMBL_101302
Residue:
693
Sequence:
MALCNGDSKLENAGGDLKDGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEIKKIPGISRIMYDLTSKPPGTTEWE
  
Inhibitor
Name:
BDBM50519498
Synonyms:
Decoyinine
Type:
Small organic molecule
Emp. Form.:
C11H13N5O4
Mol. Mass.:
279.252
SMILES:
Nc1ncnc2n(cnc12)[C@]1(CO)OC(=C)[C@@H](O)[C@H]1O
Structure:
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