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Target
Steryl-sulfatase
Ligand
BDBM50073853
Substrate
n/a
Meas. Tech.
ChEBML_68012
Ki
35900±n/a nM
Citation
 Chu, GH; Peters, A; Selcer, KW; Li, PK Synthesis and sulfatase inhibitory activities of (E)- and (Z)-4-hydroxytamoxifen sulfamates. Bioorg Med Chem Lett 9:141-4 (1999) [PubMed]  Article 
Target
Name:
Steryl-sulfatase
Synonyms:
ASC | Arylsulfatase C | STS_RAT | Steroid sulfatase | Steryl-sulfatase precursor | Steryl-sulfate sulfohydrolase | Sts
Type:
PROTEIN
Mol. Mass.:
62690.14
Organism:
Rattus norvegicus
Description:
ChEMBL_68012
Residue:
577
Sequence:
MLWPCLLALLLSQLNFLCAARPGPGPNFLLIMADDLGIGDLGCYGNRTLRTPHIDRLALEGVKLTQHLAAAPLCTPSRAAFLTGRYPVRSGMASHGRLGVFLFSASSGGLPPNEVTFAKLLKGQGYTTGLVGKWHLGLSCQAASDFCHHPGRHGFDRFLGTPTTNLRDCKPGGGTVFGSAQQVFVVLPMNILGAVLLAMALARWAGLARPPGWVFGVTVAAMAAVGGAYVAFLYHFRPANCFLMADFTITQQPTDYKGLTQRLASEAGDFLRRNRDTPFLLFLSFMHVHTAHFANPEFAGQSLHGAYGDAVEEMDWAVGQVLATLDKLGLANNTLVYLTSDHGAHVEELGPNGERHGGSNGIYRGGKANTWEGGIRVPGLVRWPGVIVPGQEVEEPTSNMDVFPTVARLAGAELPTDRVIDGRDLMPLLLGHVQHSEHEFLFHYCNAYLSAVAWRPHNSSSVWKAFYFTPNFDPPGSNGCFSTHVCMCHGHHVTHHDPPLLFDIARDPRERHPLTPETEPRHGEILRNMDAAARAHVATLEEAPNQLSMSNVAWKPWLQLCLPSKPHPLACRCAGDG
  
Inhibitor
Name:
BDBM50073853
Synonyms:
CHEMBL33862 | Sulfamic acid 4-{(E)-1-[4-(2-dimethylamino-ethoxy)-phenyl]-2-phenyl-but-1-enyl}-phenyl ester
Type:
Small organic molecule
Emp. Form.:
C26H30N2O4S
Mol. Mass.:
466.592
SMILES:
CC\C(=C(\c1ccc(OCCN(C)C)cc1)c1ccc(OS(N)(=O)=O)cc1)c1ccccc1
Structure:
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