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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50519976
Substrate
n/a
Meas. Tech.
ChEMBL_1878790 (CHEMBL4380184)
IC50
22500±n/a nM
Citation
 Kalaba, P; Ili?, M; Aher, NY; Draga?evi?, V; Wieder, M; Zehl, M; Wackerlig, J; Beyl, S; Sartori, SB; Ebner, K; Roller, A; Lukic, N; Beryozkina, T; Gonzalez, ERP; Neill, P; Khan, JA; Bakulev, V; Leban, JJ; Hering, S; Pifl, C; Singewald, N; Lubec, J; Urban, E; Sitte, HH; Langer, T; Lubec, G Structure-Activity Relationships of Novel Thiazole-Based Modafinil Analogues Acting at Monoamine Transporters. J Med Chem 63:391-417 (2020) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | DAT | DAT1 | Dopamine transporter (DAT) | Dopamine transporter protein (DAT) | Monoamine transporter | SC6A3_HUMAN | SLC6A3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) | Solute carrier family 6 member 3
Type:
Multi-pass membrane protein
Mol. Mass.:
68497.11
Organism:
Homo sapiens (Human)
Description:
Q01959
Residue:
620
Sequence:
MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKDRELVDRGEVRQFTLRHWLKV
  
Inhibitor
Name:
BDBM50519976
Synonyms:
CHEMBL4461901
Type:
Small organic molecule
Emp. Form.:
C17H13F2NOS2
Mol. Mass.:
349.418
SMILES:
[O-][S@+](Cc1cncs1)C(c1ccc(F)cc1)c1ccc(F)cc1 |r|
Structure:
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