Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM50520100
Substrate
n/a
Meas. Tech.
ChEMBL_1879035 (CHEMBL4380429)
IC50
14±n/a nM
Citation
 Yang, JJ; Yu, WW; Hu, LL; Liu, WJ; Lin, XH; Wang, W; Zhang, Q; Wang, PL; Tang, SW; Wang, X; Liu, M; Lu, W; Zhang, HK Discovery and Characterization of 1 J Med Chem 63:569-590 (2020) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Homo sapiens (Human)
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM50520100
Synonyms:
CHEMBL4576681
Type:
Small organic molecule
Emp. Form.:
C24H21F3N4O3
Mol. Mass.:
470.4437
SMILES:
C\C=C\c1nnn(Cc2ccc(cc2)C(F)(F)F)c1C(=O)NC1(CC1)c1ccc(cc1)C(O)=O
Structure:
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