Reaction Details Report a problem with these data
Target
Pro-cathepsin H
Ligand
BDBM50074049
Substrate
n/a
Meas. Tech.
ChEMBL_216701 (CHEMBL820313)
Ki
260000±n/a nM
Citation
 Schirmeister, T New peptidic cysteine protease inhibitors derived from the electrophilic alpha-amino acid aziridine-2,3-dicarboxylic acid. J Med Chem 42:560-72 (1999) [PubMed]  Article 
Target
Name:
Pro-cathepsin H
Synonyms:
CATH_HUMAN | CBSP | CPSB | CTSH | Cathepsin H | Cathepsin H heavy chain | Cathepsin H light chain | Cathepsin H mini chain
Type:
PROTEIN
Mol. Mass.:
37402.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1459870
Residue:
335
Sequence:
MWATLPLLCAGAWLLGVPVCGAAELCVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFASNWRKINAHNNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSVDWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMVEAVALYNPVSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVKNSWGPQWGMNGYFLIERGKNMCGLAACASYPIPLV
  
Inhibitor
Name:
BDBM50074049
Synonyms:
3-((S)-1-Benzyloxycarbonyl-3-methyl-butylcarbamoyl)-aziridine-2-carboxylic acid ethyl ester | CHEMBL152803
Type:
Small organic molecule
Emp. Form.:
C19H26N2O5
Mol. Mass.:
362.4201
SMILES:
CCOC(=O)C1NC1C(=O)N[C@@H](CC(C)C)C(=O)OCc1ccccc1
Structure:
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