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Target
Asialoglycoprotein receptor 1
Ligand
BDBM50074091
Substrate
n/a
Meas. Tech.
ChEMBL_36369 (CHEMBL650120)
Ki
93±n/a nM
Citation
 Sliedregt, LA; Rensen, PC; Rump, ET; van Santbrink, PJ; Bijsterbosch, MK; Valentijn, AR; van der Marel, GA; van Boom, JH; van Berkel, TJ; Biessen, EA Design and synthesis of novel amphiphilic dendritic galactosides for selective targeting of liposomes to the hepatic asialoglycoprotein receptor. J Med Chem 42:609-18 (1999) [PubMed]  Article 
Target
Name:
Asialoglycoprotein receptor 1
Synonyms:
ASGP-R 1 | ASGPR 1 | ASGR1_MOUSE | Asgr-1 | Asgr1 | HL-1 | Hepatic lectin 1 | mHL-1
Type:
PROTEIN
Mol. Mass.:
32590.63
Organism:
Mus musculus
Description:
ChEMBL_36369
Residue:
284
Sequence:
MTKDYQDFQHLDNDNDHHQLRRGPPPTPRLLQRLCSGSRLLLLSSSLSILLLVVVCVITSQNSQLREDLLALRQNFSNLTVSTEDQVKALSTQGSSVGRKMKLVESKLEKQQKDLTEDHSSLLLHVKQLVSDVRSLSCQMAAFRGNGSERTCCPINWVEYEGSCYWFSSSVRPWTEADKYCQLENAHLVVVTSRDEQNFLQRHMGPLNTWIGLTDQNGPWKWVDGTDYETGFQNWRPEQPDNWYGHGLGGGEDCAHFTTDGRWNDDVCRRPYRWVCETKLDKAN
  
Inhibitor
Name:
BDBM50074091
Synonyms:
CHEMBL2368208 | Galactoside analogue
Type:
Small organic molecule
Emp. Form.:
C65H104N8O33
Mol. Mass.:
1525.5551
SMILES:
OC[C@@H]1O[C@@H](OCCCCC(=O)NCC(=O)NCCCC(=O)OCC(COC(=O)CCCNC(=O)CNC(=O)CCCCO[C@@H]2O[C@@H](CO)[C@H](O)[C@H](O)[C@@H]2O)(COC(=O)CCCNC(=O)CNC(=O)CCCCO[C@@H]2O[C@@H](CO)[C@H](O)[C@H](O)[C@@H]2O)NC(=O)CNC(=O)OCc2ccccc2)[C@@H](O)[C@@H](O)[C@H]1O
Structure:
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