Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50074512
Substrate
n/a
Meas. Tech.
ChEMBL_51114 (CHEMBL664960)
Ki
5.2±n/a nM
Citation
 Chorvat, RJ; Bakthavatchalam, R; Beck, JP; Gilligan, PJ; Wilde, RG; Cocuzza, AJ; Hobbs, FW; Cheeseman, RS; Curry, M; Rescinito, JP; Krenitsky, P; Chidester, D; Yarem, JA; Klaczkiewicz, JD; Hodge, CN; Aldrich, PE; Wasserman, ZR; Fernandez, CH; Zaczek, R; Fitzgerald, LW; Huang, SM; Shen, HL; Wong, YN; Chien, BM; Arvanitis, A Synthesis, corticotropin-releasing factor receptor binding affinity, and pharmacokinetic properties of triazolo-, imidazo-, and pyrrolopyrimidines and -pyridines. J Med Chem 42:833-48 (1999) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50074512
Synonyms:
Butyl-[9-(2-chloro-4,6-dimethoxy-phenyl)-2-methyl-9H-purin-6-yl]-ethyl-amine | CHEMBL355721
Type:
Small organic molecule
Emp. Form.:
C20H26ClN5O2
Mol. Mass.:
403.906
SMILES:
CCCCN(CC)c1nc(C)nc2n(cnc12)-c1c(Cl)cc(OC)cc1OC |(15.41,-2.57,;14.07,-1.8,;12.72,-2.57,;11.39,-1.8,;10.06,-2.57,;8.73,-1.8,;8.73,-.24,;10.06,-4.11,;8.73,-4.88,;8.73,-6.42,;7.38,-7.19,;10.06,-7.19,;11.39,-6.42,;12.86,-6.89,;13.75,-5.63,;12.86,-4.39,;11.39,-4.88,;13.18,-8.38,;14.64,-8.87,;15.78,-7.82,;14.96,-10.37,;13.84,-11.39,;14.17,-12.91,;13.04,-13.96,;12.37,-10.93,;12.04,-9.43,;10.57,-8.96,;9.43,-9.99,)|
Structure:
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