Reaction Details Report a problem with these data
Target
GTPase HRas
Ligand
BDBM50520327
Substrate
n/a
Meas. Tech.
ChEMBL_1879629 (CHEMBL4381023)
Kd
51±n/a nM
Citation
 Erlanson, DA; de Esch, IJP; Jahnke, W; Johnson, CN; Mortenson, PN Fragment-to-Lead Medicinal Chemistry Publications in 2018. J Med Chem 63:4430-4444 (2020) [PubMed]  Article 
Target
Name:
GTPase HRas
Synonyms:
GTPase HRas, N-terminally processed | H-Ras | H-Ras-1 | HRAS | HRAS1 | Ha-Ras | His6-Ha-Ras-CVLS | RASH_HUMAN | Transforming protein p21 | Transforming protein p21/H-Ras-1 | Wild-type Ha-Ras | c-H-ras | p21ras
Type:
Other Protein Type
Mol. Mass.:
21293.37
Organism:
Homo sapiens (Human)
Description:
P01112
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS
  
Inhibitor
Name:
BDBM50520327
Synonyms:
CHEMBL4456044
Type:
Small organic molecule
Emp. Form.:
C23H25N3O3
Mol. Mass.:
391.4629
SMILES:
COc1nc(ccc1Nc1ccc(CN(C)C)cc1)-c1cccc2OCCOc12
Structure:
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