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Target
Beta-2 adrenergic receptor
Ligand
BDBM50520335
Substrate
n/a
Meas. Tech.
ChEMBL_1879630 (CHEMBL4381024)
IC50
<1.000000±n/a nM
Citation
 Erlanson, DA; de Esch, IJP; Jahnke, W; Johnson, CN; Mortenson, PN Fragment-to-Lead Medicinal Chemistry Publications in 2018. J Med Chem 63:4430-4444 (2020) [PubMed]  Article 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Type:
n/a
Mol. Mass.:
46461.69
Organism:
Homo sapiens (Human)
Description:
P07550
Residue:
413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
  
Inhibitor
Name:
BDBM50520335
Synonyms:
CHEMBL4465173
Type:
Small organic molecule
Emp. Form.:
C18H15Cl2N3
Mol. Mass.:
344.238
SMILES:
Clc1ccc(CNCc2ccc(cc2)-c2ncccn2)cc1Cl
Structure:
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