Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50070211
Substrate
n/a
Meas. Tech.
ChEMBL_86897 (CHEMBL698407)
Ki
2.9±n/a nM
Citation
 Ali, SM; Tedford, CE; Gregory, R; Handley, MK; Yates, SL; Hirth, WW; Phillips, JG Design, synthesis, and structure-activity relationships of acetylene-based histamine H3 receptor antagonists. J Med Chem 42:903-9 (1999) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50070211
Synonyms:
4-(6-Cyclohexyl-hex-3-ynyl)-1H-imidazole | CHEMBL15000 | GT 2260
Type:
Small organic molecule
Emp. Form.:
C15H22N2
Mol. Mass.:
230.3486
SMILES:
C(CC1CCCCC1)C#CCCc1cnc[nH]1
Structure:
Search PDB for entries with ligand similarity: