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Target
Growth factor receptor-bound protein 2
Ligand
BDBM50074713
Substrate
n/a
Meas. Tech.
ChEMBL_72369 (CHEMBL680932)
IC50
1630±n/a nM
Citation
 Ettmayer, P; France, D; Gounarides, J; Jarosinski, M; Martin, MS; Rondeau, JM; Sabio, M; Topiol, S; Weidmann, B; Zurini, M; Bair, KW Structural and conformational requirements for high-affinity binding to the SH2 domain of Grb2(1). J Med Chem 42:971-80 (1999) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50074713
Synonyms:
CHEMBL367276 | Phosphoric acid mono-{4-[(S)-2-((S)-1-{(S)-1-[(S)-1-((S)-2-butylcarbamoyl-pyrrolidine-1-carbonyl)-2-methyl-propylcarbamoyl]-2-carbamoyl-ethylcarbamoyl}-2-methyl-propylcarbamoyl)-2-propionylamino-ethyl]-phenyl} ester
Type:
Small organic molecule
Emp. Form.:
C35H56N7O11P
Mol. Mass.:
781.8332
SMILES:
CCCCNC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)CC)C(C)C)C(C)C
Structure:
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