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Target
Growth factor receptor-bound protein 2
Ligand
BDBM50074715
Substrate
n/a
Meas. Tech.
ChEMBL_72369 (CHEMBL680932)
IC50
60±n/a nM
Citation
 Ettmayer, P; France, D; Gounarides, J; Jarosinski, M; Martin, MS; Rondeau, JM; Sabio, M; Topiol, S; Weidmann, B; Zurini, M; Bair, KW Structural and conformational requirements for high-affinity binding to the SH2 domain of Grb2(1). J Med Chem 42:971-80 (1999) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50074715
Synonyms:
CHEMBL433805 | Phosphoric acid mono-[4-((5S,8R,11S,14R,17S,23aR)-8-carbamoylmethyl-5,11-diisopropyl-4,7,10,13,16,23-hexaoxo-17-thioacetylamino-docosahydro-3a,6,9,12,15,22-hexaaza-cyclopentacyclodocosen-14-ylmethyl)-phenyl] ester
Type:
Small organic molecule
Emp. Form.:
C36H55N8O11PS
Mol. Mass.:
838.908
SMILES:
CC(C)[C@@H]1NC(=O)[C@@H](Cc2ccc(OP(O)(O)=O)cc2)NC(=O)[C@H](CCCCNC(=O)[C@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](CC(N)=O)NC1=O)C(C)C)NC(C)=S
Structure:
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