Reaction Details Report a problem with these data
Target
Glucagon receptor
Ligand
BDBM50075750
Substrate
n/a
Meas. Tech.
ChEBML_73000
IC50
500±n/a nM
Citation
 de Laszlo, SE; Hacker, C; Li, B; Kim, D; MacCoss, M; Mantlo, N; Pivnichny, JV; Colwell, L; Koch, GE; Cascieri, MA; Hagmann, WK Potent, orally absorbed glucagon receptor antagonists. Bioorg Med Chem Lett 9:641-6 (1999) [PubMed]  Article 
Target
Name:
Glucagon receptor
Synonyms:
GL-R | GLR_MOUSE | Gcgr
Type:
PROTEIN
Mol. Mass.:
54941.21
Organism:
Mus musculus
Description:
ChEMBL_1338729
Residue:
485
Sequence:
MPLTQLHCPHLLLLLLVLSCLPEAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQPWRNASQCQLDDEEIEVQKGVAKMYSSQQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAMAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSLATFSERSFFSLYLGIGWGAPLLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVFLALLINFFIFVHIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFLSSFQGLLVAVLYCFLNKEVQAELMRRWRQWQEGKALQEERLASSHGSHMAPAGPCHGDPCEKLQLMSAGSSSGTGCVPSMETSLASSLPRLADSPT
  
Inhibitor
Name:
BDBM50075750
Synonyms:
5-(4-Chloro-phenyl)-2-pyridin-4-yl-1H-pyrrole-3-carboxylic acid ethyl ester | CHEMBL345863
Type:
Small organic molecule
Emp. Form.:
C18H15ClN2O2
Mol. Mass.:
326.777
SMILES:
CCOC(=O)c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: