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Target
Glucagon receptor
Ligand
BDBM50075753
Substrate
n/a
Meas. Tech.
ChEBML_73000
IC50
430±n/a nM
Citation
 de Laszlo, SE; Hacker, C; Li, B; Kim, D; MacCoss, M; Mantlo, N; Pivnichny, JV; Colwell, L; Koch, GE; Cascieri, MA; Hagmann, WK Potent, orally absorbed glucagon receptor antagonists. Bioorg Med Chem Lett 9:641-6 (1999) [PubMed]  Article 
Target
Name:
Glucagon receptor
Synonyms:
GL-R | GLR_MOUSE | Gcgr
Type:
PROTEIN
Mol. Mass.:
54941.21
Organism:
Mus musculus
Description:
ChEMBL_1338729
Residue:
485
Sequence:
MPLTQLHCPHLLLLLLVLSCLPEAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQPWRNASQCQLDDEEIEVQKGVAKMYSSQQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAMAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSLATFSERSFFSLYLGIGWGAPLLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVFLALLINFFIFVHIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFLSSFQGLLVAVLYCFLNKEVQAELMRRWRQWQEGKALQEERLASSHGSHMAPAGPCHGDPCEKLQLMSAGSSSGTGCVPSMETSLASSLPRLADSPT
  
Inhibitor
Name:
BDBM50075753
Synonyms:
4-[3,5-Bis-(4-fluoro-phenyl)-1H-pyrrol-2-yl]-pyridine | CHEMBL157529
Type:
Small organic molecule
Emp. Form.:
C21H14F2N2
Mol. Mass.:
332.3461
SMILES:
Fc1ccc(cc1)-c1cc(c([nH]1)-c1ccncc1)-c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: