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Target
Prostaglandin E2 receptor EP2 subtype
Ligand
BDBM50142481
Substrate
n/a
Meas. Tech.
ChEMBL_1884832 (CHEMBL4386414)
Ki
1459±n/a nM
Citation
 Barrett, SD; Holt, MC; Kramer, JB; Germain, B; Ho, CS; Ciske, FL; Kornilov, A; Colombo, JM; Uzieblo, A; O'Malley, JP; Owen, TA; Stein, AJ; Morano, MI Difluoromethylene at the ?-Lactam ?-Position Improves 11-Deoxy-8-aza-PGE J Med Chem 62:4731-4741 (2019) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP2 subtype
Synonyms:
PE2R2_HUMAN | PGE receptor EP2 subtype | PTGER2 | Prostaglandin E2 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP4 subtype | Prostanoid EP2 Receptor
Type:
Enzyme
Mol. Mass.:
39775.71
Organism:
Homo sapiens (Human)
Description:
P43116
Residue:
358
Sequence:
MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
  
Inhibitor
Name:
BDBM50142481
Synonyms:
7-[(R)-2-((E)-(S)-3-Hydroxy-oct-1-enyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid | 8-aza-11-deoxyprostaglandin E1 | CHEMBL42027
Type:
Small organic molecule
Emp. Form.:
C19H33NO4
Mol. Mass.:
339.4696
SMILES:
CCCCC[C@H](O)\C=C\[C@H]1CCC(=O)N1CCCCCCC(O)=O
Structure:
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