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Target
Polypeptide N-acetylgalactosaminyltransferase 2
Ligand
BDBM50521707
Substrate
n/a
Meas. Tech.
ChEMBL_1885029 (CHEMBL4386611)
IC50
>100000±n/a nM
Citation
 Liu, F; Cui, Y; Yang, F; Xu, Z; Da, LT; Zhang, Y Inhibition of polypeptide N-acetyl-?-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis. Bioorg Med Chem 27:3372-3382 (2019) [PubMed]  Article 
Target
Name:
Polypeptide N-acetylgalactosaminyltransferase 2
Synonyms:
GALNT2 | GALT2_HUMAN | GalNAc-T2 | Polypeptide GalNAc transferase 2 | Polypeptide N-acetylgalactosaminyltransferase 2 | Polypeptide N-acetylgalactosaminyltransferase 2 soluble form | Protein-UDP acetylgalactosaminyltransferase 2 | UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2 | pp-GaNTase 2
Type:
PROTEIN
Mol. Mass.:
64746.16
Organism:
Homo sapiens (Human)
Description:
ChEMBL_115316
Residue:
571
Sequence:
MRRRSRMLLCFAFLWVLGIAYYMYSGGGSALAGGAGGGAGRKEDWNEIDPIKKKDLHHSNGEEKAQSMETLPPGKVRWPDFNQEAYVGGTMVRSGQDPYARNKFNQVESDKLRMDRAIPDTRHDQCQRKQWRVDLPATSVVITFHNEARSALLRTVVSVLKKSPPHLIKEIILVDDYSNDPEDGALLGKIEKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNEHWLEPLLERVAEDRTRVVSPIIDVINMDNFQYVGASADLKGGFDWNLVFKWDYMTPEQRRSRQGNPVAPIKTPMIAGGLFVMDKFYFEELGKYDMMMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPGGSGTVFARNTRRAAEVWMDEYKNFYYAAVPSARNVPYGNIQSRLELRKKLSCKPFKWYLENVYPELRVPDHQDIAFGALQQGTNCLDTLGHFADGVVGVYECHNAGGNQEWALTKEKSVKHMDLCLTVVDRAPGSLIKLQGCRENDSRQKWEQIEGNSKLRHVGSNLCLDSRTAKSGGLSVEVCGPALSQQWKFTLNLQQ
  
Inhibitor
Name:
BDBM50521707
Synonyms:
CHEMBL487203
Type:
Small organic molecule
Emp. Form.:
C16H10O8
Mol. Mass.:
330.2458
SMILES:
COc1c(O)cc2c3c1oc(=O)c1cc(O)c(OC)c(oc2=O)c31
Structure:
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