Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50076758
Substrate
n/a
Meas. Tech.
ChEBML_50975
Ki
9.4±n/a nM
Citation
 Cocuzza, AJ; Hobbs, FW; Arnold, CR; Chidester, DR; Yarem, JA; Culp, S; Fitzgerald, L; Gilligan, PJ 4-Aryl-2-anilinopyrimidines as corticotropin-releasing hormone (CRH) antagonists. Bioorg Med Chem Lett 9:1057-62 (1999) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50076758
Synonyms:
2-Bromo-N*1*-ethyl-6-methoxy-N*4*,N*4*-dimethyl-N*1*-[4-methyl-6-(2-trifluoromethyl-phenyl)-pyrimidin-2-yl]-benzene-1,4-diamine | CHEMBL10015
Type:
Small organic molecule
Emp. Form.:
C23H24BrF3N4O
Mol. Mass.:
509.362
SMILES:
CCN(c1nc(C)cc(n1)-c1ccccc1C(F)(F)F)c1c(Br)cc(cc1OC)N(C)C
Structure:
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