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Target
DNA repair protein RAD51 homolog 1
Ligand
BDBM48804
Substrate
n/a
Meas. Tech.
ChEMBL_1885395 (CHEMBL4386977)
IC50
6000±n/a nM
Citation
 Radhakrishnan, S; Syed, R; Takei, H; Kobayashi, IS; Nakamura, E; Sultana, F; Kamal, A; Tenen, DG; Kobayashi, SS Styryl quinazolinones and its ethynyl derivatives induce myeloid differentiation. Bioorg Med Chem Lett 29:2286-2289 (2019) [PubMed]  Article 
Target
Name:
DNA repair protein RAD51 homolog 1
Synonyms:
RAD51 | RAD51A | RAD51_HUMAN | RECA
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36960.74
Organism:
Homo sapiens (Human)
Description:
gi_49168602
Residue:
339
Sequence:
MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKELINIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD
  
Inhibitor
Name:
BDBM48804
Synonyms:
3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-quinazolinone | 3-(phenylmethyl)-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one | 3-benzyl-2-[(E)-2-(3-pyridyl)vinyl]quinazolin-4-one | 3-benzyl-2-[(E)-2-pyridin-3-ylethenyl]quinazolin-4-one | MLS000709026 | SMR000289793 | cid_5738263
Type:
Small organic molecule
Emp. Form.:
C22H17N3O
Mol. Mass.:
339.3899
SMILES:
O=c1n(Cc2ccccc2)c(\C=C\c2cccnc2)nc2ccccc12
Structure:
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