Reaction Details Report a problem with these data
Target
Farnesyl diphosphate synthase
Ligand
BDBM50521853
Substrate
n/a
Meas. Tech.
ChEMBL_1885449 (CHEMBL4387031)
IC50
88±n/a nM
Citation
 Galaka, T; Falcone, BN; Li, C; Szajnman, SH; Moreno, SNJ; Docampo, R; Rodriguez, JB Synthesis and biological evaluation of 1-alkylaminomethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii. Bioorg Med Chem 27:3663-3673 (2019) [PubMed]  Article 
Target
Name:
Farnesyl diphosphate synthase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
69493.18
Organism:
Toxoplasma gondii
Description:
ChEMBL_1282507
Residue:
646
Sequence:
MVDAVSLVSCRARHSHSLFAFSLSRRSCIQKHRFFSYVKSVPSSLPSPSSSSSPFTLSPRRRCLPPLVLPLEAAGHLPPALHSGSGISCPRSSSLSLSSSSPMRAPPSISLGLPPAQRPSLCFSPTSRLSAPVSPWSFSRQLSLATLAPLASVSSWKKAAALPKPDGAAAVSDERTSAERADALAGAWRASASHVEDRFKQAFPEVRGTLLSHIAGLDLPASLSARLLSYYARLLDYTCSGGKLTRGILVLYAAAAASHAPVLPPPSPSPAAAPASSASSVSSSPCSSSLAESERVPGSALSPALPPSSFRCLAALGWCVELLQSCFLVMDDVMDHSLTRRGKQCWYRCDGIGVSNAVNDSLVLEAAVYRVLREYLGDHPAYVQLQDLLLGNTFTTLIGQHLDSEDALAALSEASQNLESRQSEDNSSASSATAAGSSLLRDASLSDKDFTHHSYVSSSLSSSRSSPSLSASSLPSSEVLAQKLADRQATVARLKTSHYSFYLPTALGMTYGGLTDPALMAQAKELCLAIGEYFQVQDDYLDCFSDPKISGKIGSDIQEKKCCWLFVQAVRRASREDLAQLLRVYGQPEYVDWVKDLYRRLDLTSLYFQYEEETLAKLRRSVSSFPHDGMKAFFGLVLGRLHKRQK
  
Inhibitor
Name:
BDBM50521853
Synonyms:
CHEMBL4464077
Type:
Small organic molecule
Emp. Form.:
C9H22FNO6P2
Mol. Mass.:
321.22
SMILES:
CCCCCCCNCC(F)(P(O)(O)=O)P(O)(O)=O
Structure:
Search PDB for entries with ligand similarity: