Reaction Details Report a problem with these data
Target
Anthrax toxin receptor 2
Ligand
BDBM50522447
Substrate
n/a
Meas. Tech.
ChEMBL_1886716 (CHEMBL4388393)
IC50
1164±n/a nM
Citation
 G-Doyagüez, E; Carrero, P; Madrona, A; Rodriguez-Salamanca, P; Martínez-Gualda, B; Camarasa, MJ; Jimeno, ML; Bennallack, PR; Finnell, JG; Tsang, TM; Christensen, KA; San-Félix, A; Rogers, MS Galloyl Carbohydrates with Antiangiogenic Activity Mediated by Capillary Morphogenesis Gene 2 (CMG2) Protein Binding. J Med Chem 62:3958-3970 (2019) [PubMed]  Article 
Target
Name:
Anthrax toxin receptor 2
Synonyms:
ANTR2_HUMAN | ANTXR2 | Anthrax toxin receptor 2 | CMG-2 | CMG2 | Capillary morphogenesis gene 2 protein
Type:
PROTEIN
Mol. Mass.:
53667.55
Organism:
Homo sapiens
Description:
ChEMBL_118453
Residue:
489
Sequence:
MVAERSPARSPGSWLFPGLWLLVLSGPGGLLRAQEQPSCRRAFDLYFVLDKSGSVANNWIEIYNFVQQLAERFVSPEMRLSFIVFSSQATIILPLTGDRGKISKGLEDLKRVSPVGETYIHEGLKLANEQIQKAGGLKTSSIIIALTDGKLDGLVPSYAEKEAKISRSLGASVYCVGVLDFEQAQLERIADSKEQVFPVKGGFQALKGIINSILAQSCTEILELQPSSVCVGEEFQIVLSGRGFMLGSRNGSVLCTYTVNETYTTSVKPVSVQLNSMLCPAPILNKAGETLDVSVSFNGGKSVISGSLIVTATECSNGIAAIIVILVLLLLLGIGLMWWFWPLCCKVVIKDPPPPPAPAPKEEEEEPLPTKKWPTVDASYYGGRGVGGIKRMEVRWGDKGSTEEGARLEKAKNAVVKIPEETEEPIRPRPPRPKPTHQPPQTKWYTPIKGRLDALWALLRRQYDRVSLMRPQEGDEVCIWECIEKELTA
  
Inhibitor
Name:
BDBM50522447
Synonyms:
CHEMBL4440070
Type:
Small organic molecule
Emp. Form.:
C68H54O43
Mol. Mass.:
1559.1306
SMILES:
[H][C@]1(O[C@@H]2[C@@H](COC(=O)c3ccc(O)c(O)c3O)O[C@@H](OC(=O)c3ccc(O)c(O)c3O)[C@H](OC(=O)c3ccc(O)c(O)c3O)[C@H]2OC(=O)c2ccc(O)c(O)c2O)O[C@H](COC(=O)c2ccc(O)c(O)c2O)[C@@H](OC(=O)c2ccc(O)c(O)c2O)[C@H](OC(=O)c2ccc(O)c(O)c2O)[C@H]1OC(=O)c1ccc(O)c(O)c1O |r|
Structure:
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