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Target
Dihydrofolate reductase
Ligand
BDBM50433824
Substrate
n/a
Meas. Tech.
ChEMBL_1888455 (CHEMBL4390132)
IC50
2100±n/a nM
Citation
 Shah, K; Queener, S; Cody, V; Pace, J; Gangjee, A Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection. Bioorg Med Chem Lett 29:1874-1880 (2019) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21453.99
Organism:
Homo sapiens (Human)
Description:
Recombinant human DHFR.
Residue:
187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
  
Inhibitor
Name:
BDBM50433824
Synonyms:
CHEMBL2382319
Type:
Small organic molecule
Emp. Form.:
C14H14N6
Mol. Mass.:
266.3012
SMILES:
Cc1ccc(Nc2cnc3nc(N)nc(N)c3c2)cc1
Structure:
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