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Target
Endothelial lipase
Ligand
BDBM50522804
Substrate
n/a
Meas. Tech.
ChEMBL_1888464 (CHEMBL4390141)
IC50
94±n/a nM
Citation
 Kim, SH; Johnson, JA; Jiang, J; Parkhurst, B; Phillips, M; Pi, Z; Qiao, JX; Tora, G; Ye Chen, A; Liu, E; Yin, X; Yang, R; Zhao, L; Taylor, DS; Basso, M; Behnia, K; Onorato, J; Chen, XQ; Abell, LM; Lu, H; Locke, G; Caporuscio, C; Adam, LP; Gordon, D; Wexler, RR; Finlay, HJ Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase. Bioorg Med Chem Lett 29:1918-1921 (2019) [PubMed]  Article 
Target
Name:
Endothelial lipase
Synonyms:
EDL | Endothelial cell-derived lipase | Endothelial lipase | Endothelial lipase (EL) | LIPE_MOUSE | Lipg
Type:
Protein
Mol. Mass.:
56643.58
Organism:
Mus musculus (Mouse)
Description:
Q9WVG5
Residue:
500
Sequence:
MRNTVFLLGFWSVYCYFPAGSITTLRPQGSLRDEHHKPTGVPATARPSVAFNIRTSKDPEQEGCNLSLGDSKLLENCGFNMTAKTFFIIHGWTMSGMFESWLHKLVSALQMREKDANVVVVDWLPLAHQLYTDAVNNTRVVGQRVAGMLDWLQEKEEFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGVDINRRLSPDDADFVDVLHTYTLSFGLSIGIRMPVGHIDIYPNGGDFQPGCGFNDVIGSFAYGTISEMVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSSRFKRGICLSCRKNRCNNIGYNAKKMRKKRNSKMYLKTRAGMPFKVYHYQLKVHMFSYNNSGDTQPTLYITLYGSNADSQNLPLEIVEKIELNATNTFLVYTEEDLGDLLKMRLTWEGVAHSWYNLWNEFRNYLSQPSNPSRELYIRRIRVKSGETQRKVTFCTQDPTKSSISPGQELWFHKCQDGWKMKNKTSPFVNLA
  
Inhibitor
Name:
BDBM50522804
Synonyms:
CHEMBL4437751
Type:
Small organic molecule
Emp. Form.:
C26H23FN4O4S2
Mol. Mass.:
538.614
SMILES:
Fc1ccc(cn1)-c1ccc2nc(sc2c1)C(C(=O)NCC(=O)NC1CC1)S(=O)(=O)Cc1ccccc1
Structure:
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