Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50522809
Substrate
n/a
Meas. Tech.
ChEMBL_1888527 (CHEMBL4390204)
Ki
2.3±n/a nM
Citation
 Yamashita, Y; Tanaka, KI; Yamakawa, N; Asano, T; Kanda, Y; Takafuji, A; Kawahara, M; Takenaga, M; Fukunishi, Y; Mizushima, T Chemical modification-mediated optimisation of bronchodilatory activity of mepenzolate, a muscarinic receptor antagonist with anti-inflammatory activity. Bioorg Med Chem 27:3339-3346 (2019) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:
GPCR
Mol. Mass.:
51730.61
Organism:
Homo sapiens (Human)
Description:
P08172
Residue:
466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50522809
Synonyms:
CHEMBL4540604
Type:
Small organic molecule
Emp. Form.:
C29H32BrNO3
Mol. Mass.:
522.473
SMILES:
[Br-].OC(C(=O)OC1C[N+]2(CCc3ccccc3)CCC1CC2)(c1ccccc1)c1ccccc1 |(59.77,-32.99,;51.72,-34.99,;53.06,-35.76,;54.4,-36.53,;54.4,-38.07,;55.73,-35.75,;57.07,-36.52,;58.4,-35.74,;59.72,-36.52,;61.06,-35.75,;62.39,-36.52,;63.72,-35.76,;65.05,-36.54,;66.39,-35.77,;66.39,-34.23,;65.05,-33.46,;63.72,-34.23,;59.73,-38.06,;58.4,-38.82,;57.07,-38.06,;58.56,-37.86,;58.21,-36.81,;53.06,-34.22,;54.39,-33.45,;54.39,-31.91,;53.05,-31.14,;51.71,-31.93,;51.72,-33.46,;51.73,-36.53,;50.4,-35.76,;49.07,-36.53,;49.07,-38.08,;50.42,-38.84,;51.74,-38.06,)|
Structure:
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