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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50522905
Substrate
n/a
Meas. Tech.
ChEMBL_1888674 (CHEMBL4390351)
Kd
165±n/a nM
Citation
 Follows, B; Fessler, S; Baumeister, T; Campbell, AM; Zablocki, MM; Li, H; Gotur, D; Wang, Z; Zheng, X; Molz, L; Nguyen, C; Herbertz, T; Wang, L; Bair, K Discovery of novel biaryl sulfonamide based Mcl-1 inhibitors. Bioorg Med Chem Lett 29:2375-2382 (2019) [PubMed]  Article 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50522905
Synonyms:
CHEMBL4593715
Type:
Small organic molecule
Emp. Form.:
C21H18ClF3N2O4S2
Mol. Mass.:
518.957
SMILES:
Cc1cc(sc1S(=O)(=O)Nc1cc(ccc1Cl)C(F)(F)F)C(=O)NC[C@@H](O)c1ccccc1 |r|
Structure:
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