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Target
Lysosomal acid glucosylceramidase
Ligand
BDBM50078113
Substrate
n/a
Meas. Tech.
ChEMBL_71689 (CHEMBL681681)
IC50
960.0±n/a nM
Citation
 Ogawa, S; Uetsuki, S; Tezuka, Y; Morikawa, T; Takahashi, A; Sato, K Synthesis and evaluation of glucocerebrosidase inhibitory activity of anhydro deoxyinositols from (+)-epi- and (-)-vibo-quercitols. Bioorg Med Chem Lett 9:1493-8 (1999) [PubMed]  Article 
Target
Name:
Lysosomal acid glucosylceramidase
Synonyms:
Beta-glucocerebrosidase | GBA1_MOUSE | Gba | Gba1
Type:
Enzyme
Mol. Mass.:
57628.24
Organism:
Mus musculus (Mouse)
Description:
P17439
Residue:
515
Sequence:
MAARLIGFFLFQAVSWAYGAQPCIPKSFGYSSVVCVCNASYCDSLDPVTLPALGTFSRYESTRRGRRMELSVGAIQANRTGTGLLLTLQPEKKFQKVKGFGGAMTDATALNILALSPPTQKLLLRSYFSTNGIEYNIIRVPMASCDFSIRVYTYADTPNDFQLSNFSLPEEDTKLKIPLIHQALKMSSRPISLFASPWTSPTWLKTNGRVNGKGSLKGQPGDIFHQTWANYFVKFLDAYAKYGLRFWAVTAENEPTAGLFTGYPFQCLGFTPEHQRDFISRDLGPALANSSHDVKLLMLDDQRLLLPRWAEVVLSDPEAAKYVHGIAVHWYMDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVTGWTDWNLALNPEGGPNWVRNFVDSPIIVDIPKDAFYKQPMFYHLGHFSKFIPEGSQRVALVASESTDLETVALLRPDGSAVVVVLNRSSEDVPLTISDPDLGFLETVSPGYSIHTYLWRRQ
  
Inhibitor
Name:
BDBM50078113
Synonyms:
(1S,2R,3S,4R,6R)-7-Oxa-bicyclo[4.1.0]heptane-2,3,4-triol | CHEMBL35833
Type:
Small organic molecule
Emp. Form.:
C6H10O4
Mol. Mass.:
146.1412
SMILES:
O[C@@H]1C[C@H]2O[C@H]2[C@H](O)[C@H]1O
Structure:
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