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Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM22774
Substrate
n/a
Meas. Tech.
ChEMBL_1889220 (CHEMBL4390974)
IC50
8800±n/a nM
Citation
 Calil, FA; David, JS; Chiappetta, ERC; Fumagalli, F; Mello, RB; Leite, FHA; Castilho, MS; Emery, FS; Nonato, MC Ligand-based design, synthesis and biochemical evaluation of potent and selective inhibitors of Schistosoma mansoni dihydroorotate dehydrogenase. Eur J Med Chem 167:357-366 (2019) [PubMed]  Article 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
1.3.5.2 | Dihydroorotate dehydrogenase (quinone), mitochondrial
Type:
PROTEIN
Mol. Mass.:
41300.36
Organism:
Schistosoma mansoni
Description:
ChEMBL_119667
Residue:
379
Sequence:
MSRIRTSLEVLSLGFGLFTAEALYSGNEHFYKDWFLPTARLLVRDGETAHNLSVYLASYGFIPHKQRNSFPQLKCKVFGLEFDHPIGLAAGFDKDGKAFMGLLNAGFSHIEVGTVTPNPQLGNARPRIFRWTEKEAVVNRCGFNSDGHDAVYERLKDRPWEGRGVIGVNLGCNKTSADPTADYVAGVRKFGEVADYLVINVSSPNTPGLRSLQTKEKLRDLLSKVLAARNQLSKKTPILLKISPDENDQNLKDIVEVALDSKTRIDGMIISNTTLTTYEEAVACGAAPIPGNNKQNVVYGGLSGRPLFEKSTDCLRKVSALTKGAIPLIGVGGISCGEDALSKLNAGASLVQLYTSFVYQGPPVAHKVAREINKLKMTS
  
Inhibitor
Name:
BDBM22774
Synonyms:
1,4-Benzoquinone | Benzil-related compound, 53 | CHEMBL8320 | benzoquinone | cid_4650 | cyclohexa-2,5-diene-1,4-dione
Type:
Small organic molecule
Emp. Form.:
C6H4O2
Mol. Mass.:
108.0948
SMILES:
O=C1C=CC(=O)C=C1 |c:2,6|
Structure:
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