Reaction Details Report a problem with these data
Target
Purine nucleoside phosphorylase
Ligand
BDBM50005794
Substrate
n/a
Meas. Tech.
ChEMBL_162021 (CHEMBL772961)
IC50
49646±n/a nM
Citation
 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH Structure-activity relationships for a class of inhibitors of purine nucleoside phosphorylase. J Med Chem 42:2422-31 (1999) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | NP | PNP | PNPH_BOVIN | Purine Nucleoside Phosphorylase (PNP) | Purine nucleoside phosphorylase
Type:
Enzyme
Mol. Mass.:
32035.18
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
289
Sequence:
MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG
  
Inhibitor
Name:
BDBM50005794
Synonyms:
3-Benzyl-1,9-dihydro-purin-6-one | 3-Benzyl-3,7-dihydro-purin-6-one | CHEMBL415041
Type:
Small organic molecule
Emp. Form.:
C12H10N4O
Mol. Mass.:
226.234
SMILES:
Oc1ncn(Cc2ccccc2)c2ncnc12
Structure:
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