Reaction Details Report a problem with these data
Target
Purine nucleoside phosphorylase
Ligand
BDBM50042799
Substrate
n/a
Meas. Tech.
ChEMBL_162028 (CHEMBL873419)
Ki
61±n/a nM
Citation
 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH Structure-activity relationships for a class of inhibitors of purine nucleoside phosphorylase. J Med Chem 42:2422-31 (1999) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | NP | PNP | PNPH_BOVIN | Purine Nucleoside Phosphorylase (PNP) | Purine nucleoside phosphorylase
Type:
Enzyme
Mol. Mass.:
32035.18
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
289
Sequence:
MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG
  
Inhibitor
Name:
BDBM50042799
Synonyms:
3-(2-Amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3-phenyl-propionic acid | CHEMBL79460
Type:
Small organic molecule
Emp. Form.:
C15H14N4O3
Mol. Mass.:
298.2967
SMILES:
Nc1nc2c(c[nH]c2c(=O)[nH]1)C(CC(O)=O)c1ccccc1
Structure:
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