Reaction Details
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D(4) dopamine receptor
Ligand
BDBM50523480
Substrate
n/a
Meas. Tech.
ChEMBL_1890411 (CHEMBL4392165)
Ki
42±n/a nM
Citation
Keck, TM; Free, RB; Day, MM; Brown, SL; Maddaluna, MS; Fountain, G; Cooper, C; Fallon, B; Holmes, M; Stang, CT; Burkhardt, R; Bonifazi, A; Ellenberger, MP; Newman, AH; Sibley, DR; Wu, C; Boateng, CA Dopamine D J Med Chem 62:3722-3740 (2019) [PubMed] Article More Info.:
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
Inhibitor
Name:
BDBM50523480
Synonyms:
CHEMBL4587925
Type:
Small organic molecule
Emp. Form.:
C20H25N3O
Mol. Mass.:
323.432
SMILES:
Cc1ccc(nc1)C1CCN(CC(=O)Nc2cccc(C)c2)CC1
Structure:
