Reaction Details Report a problem with these data
Target
Potassium voltage-gated channel subfamily E member 1
Ligand
BDBM50523766
Substrate
n/a
Meas. Tech.
ChEMBL_1891117 (CHEMBL4392944)
IC50
>33000±n/a nM
Citation
 Kajanus, J; Antonsson, T; Carlsson, L; Jurva, U; Pettersen, A; Sundell, J; Inghardt, T Potassium channel blocking 1,2-bis(aryl)ethane-1,2-diamines active as antiarrhythmic agents. Bioorg Med Chem Lett 29:1241-1245 (2019) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily E member 1
Synonyms:
Delayed rectifier potassium channel subunit IsK | IKs producing slow voltage-gated potassium channel subunit beta Mink | KCNE1 | KCNE1_HUMAN | KCNQ1(Kv7.1)/KCNE1(MinK) | Minimal potassium channel | Voltage-gated potassium channel beta subunit Mink | Voltage-gated potassium channel, IKs
Type:
PROTEIN
Mol. Mass.:
14676.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1456351
Residue:
129
Sequence:
MILSNTTAVTPFLTKLWQETVQQGGNMSGLARRSPRSSDGKLEALYVLMVLGFFGFFTLGIMLSYIRSKKLEHSNDPFNVYIESDAWQEKDKAYVQARVLESYRSCYVVENHLAIEQPNTHLPETKPSP
  
Inhibitor
Name:
BDBM50523766
Synonyms:
CHEMBL4476275
Type:
Small organic molecule
Emp. Form.:
C24H38N4
Mol. Mass.:
382.5853
SMILES:
CCCN(CCC)[C@@H]([C@H](N(CCC)CCC)c1ccccn1)c1ccccn1 |r|
Structure:
Search PDB for entries with ligand similarity: