Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 1
Ligand
BDBM50078983
Substrate
n/a
Meas. Tech.
ChEMBL_143983 (CHEMBL752582)
Ki
3800±n/a nM
Citation
 Murakami, Y; Hara, H; Okada, T; Hashizume, H; Kii, M; Ishihara, Y; Ishikawa, M; Shimamura, M; Mihara, S; Kato, G; Hanasaki, K; Hagishita, S; Fujimoto, M 1,3-Disubstituted benzazepines as novel, potent, selective neuropeptide Y Y1 receptor antagonists. J Med Chem 42:2621-32 (1999) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 1
Synonyms:
NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44399.07
Organism:
Homo sapiens (Human)
Description:
NPY-Y1 NPY1R HUMAN::P25929
Residue:
384
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
  
Inhibitor
Name:
BDBM50078983
Synonyms:
CHEMBL314662 | N-Isopropyl-2-{3-[2-oxo-3-(3-phenyl-ureido)-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl]-phenyl}-acetamide
Type:
Small organic molecule
Emp. Form.:
C29H32N4O3
Mol. Mass.:
484.5894
SMILES:
CC(C)NC(=O)Cc1cccc(CN2c3ccccc3CCC(NC(=O)Nc3ccccc3)C2=O)c1
Structure:
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