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Target
Beta-lactamase
Ligand
BDBM50079683
Substrate
n/a
Meas. Tech.
ChEMBL_41360 (CHEMBL656039)
IC50
44510±n/a nM
Citation
 Buynak, JD; Rao, AS; Doppalapudi, VR; Adam, G; Petersen, PJ; Nidamarthy, SD The synthesis and evaluation of 6-alkylidene-2'beta-substituted penam sulfones as beta-lactamase inhibitors. Bioorg Med Chem Lett 9:1997-2002 (1999) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
BLAC_STAAU | Beta-lactamase TEM | Penicillinase | blaZ
Type:
PROTEIN
Mol. Mass.:
31367.53
Organism:
Staphylococcus aureus
Description:
ChEMBL_41052
Residue:
281
Sequence:
MKKLIFLIVIALVLSACNSNSSHAKELNDLEKKYNAHIGVYALDTKSGKEVKFNSDKRFAYASTSKAINSAILLEQVPYNKLNKKVHINKDDIVAYSPILEKYVGKDITLKALIEASMTYSDNTANNKIIKEIGGIKKVKQRLKELGDKVTNPVRYEIELNYYSPKSKKDTSTPAAFGKTLNKLIANGKLSKENKKFLLDLMLNNKSGDTLIKDGVPKDYKVADKSGQAITYASRNDVAFVYPKGQSEPIVLVIFTNKDNKSDKPNDKLISETAKSVMKEF
  
Inhibitor
Name:
BDBM50079683
Synonyms:
CHEMBL292147 | Sodium; (2S,3R)-3-chloromethyl-6-[1-methoxycarbonyl-meth-(Z)-ylidene]-3-methyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C11H11ClNO7S
Mol. Mass.:
336.726
SMILES:
COC(=O)\C=C1/C2N([C@@H](C([O-])=O)[C@](C)(CCl)S2(=O)=O)C1=O
Structure:
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