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Target
Beta-lactamase
Ligand
BDBM50079692
Substrate
n/a
Meas. Tech.
ChEMBL_41360 (CHEMBL656039)
IC50
233±n/a nM
Citation
 Buynak, JD; Rao, AS; Doppalapudi, VR; Adam, G; Petersen, PJ; Nidamarthy, SD The synthesis and evaluation of 6-alkylidene-2'beta-substituted penam sulfones as beta-lactamase inhibitors. Bioorg Med Chem Lett 9:1997-2002 (1999) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
BLAC_STAAU | Beta-lactamase TEM | Penicillinase | blaZ
Type:
PROTEIN
Mol. Mass.:
31367.53
Organism:
Staphylococcus aureus
Description:
ChEMBL_41052
Residue:
281
Sequence:
MKKLIFLIVIALVLSACNSNSSHAKELNDLEKKYNAHIGVYALDTKSGKEVKFNSDKRFAYASTSKAINSAILLEQVPYNKLNKKVHINKDDIVAYSPILEKYVGKDITLKALIEASMTYSDNTANNKIIKEIGGIKKVKQRLKELGDKVTNPVRYEIELNYYSPKSKKDTSTPAAFGKTLNKLIANGKLSKENKKFLLDLMLNNKSGDTLIKDGVPKDYKVADKSGQAITYASRNDVAFVYPKGQSEPIVLVIFTNKDNKSDKPNDKLISETAKSVMKEF
  
Inhibitor
Name:
BDBM50079692
Synonyms:
CHEMBL292506 | Disodium; (2S,3R)-6-[1-carboxy-meth-(Z)-ylidene]-3-methyl-3-[2-(1-methyl-1H-tetrazol-5-ylsulfanyl)-acetoxymethyl]-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C14H13N5O9S2
Mol. Mass.:
459.412
SMILES:
Cn1nnnc1SCC(=O)OC[C@@]1(C)[C@@H](N2C(\C(=C/C([O-])=O)C2=O)S1(=O)=O)C([O-])=O
Structure:
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