Reaction Details Report a problem with these data
Target
Imidazoleglycerol-phosphate dehydratase
Ligand
BDBM50079736
Substrate
n/a
Meas. Tech.
ChEMBL_90659 (CHEMBL700890)
IC50
16000±n/a nM
Citation
 Schweitzer, BA; Loida, PJ; Thompson-Mize, RL; CaJacob, CA; Hegde, SG Design and synthesis of beta-carboxamido phosphonates as potent inhibitors of imidazole glycerol phosphate dehydratase. Bioorg Med Chem Lett 9:2053-8 (1999) [PubMed]  Article 
Target
Name:
Imidazoleglycerol-phosphate dehydratase
Synonyms:
HIS3 | HIS7_CRYNB | IGPD
Type:
PROTEIN
Mol. Mass.:
21976.83
Organism:
Cryptococcus neoformans
Description:
ChEMBL_90660
Residue:
202
Sequence:
MSERIASVERTTSETHISCTIDLDHIPGVTEQKINVSTGIGFLDHMFTALAKHGGMSLQLQCKGDLHIDDHHTAEDCALALGEAFKKALGERKGIKRYGYAYAPLDESLSRAVIDISSRPYFMCHLPFTREKVGDLSTEMVSHLLQSFAFAAGVTLHIDSIRGENNHHIAESAFKALALAIRMAISRTGGDDVPSTKGVLAL
  
Inhibitor
Name:
BDBM50079736
Synonyms:
CHEMBL64951 | [2-(2-Hydroxy-benzoylamino)-3-[1,2,4]triazol-1-yl-propyl]-phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C12H15N4O5P
Mol. Mass.:
326.2451
SMILES:
Oc1ccccc1C(=O)NC(Cn1cncn1)CP(O)(O)=O
Structure:
Search PDB for entries with ligand similarity: