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Target
Imidazoleglycerol-phosphate dehydratase
Ligand
BDBM50079730
Substrate
n/a
Meas. Tech.
ChEMBL_90659 (CHEMBL700890)
IC50
4100±n/a nM
Citation
 Schweitzer, BA; Loida, PJ; Thompson-Mize, RL; CaJacob, CA; Hegde, SG Design and synthesis of beta-carboxamido phosphonates as potent inhibitors of imidazole glycerol phosphate dehydratase. Bioorg Med Chem Lett 9:2053-8 (1999) [PubMed]  Article 
Target
Name:
Imidazoleglycerol-phosphate dehydratase
Synonyms:
HIS3 | HIS7_CRYNB | IGPD
Type:
PROTEIN
Mol. Mass.:
21976.83
Organism:
Cryptococcus neoformans
Description:
ChEMBL_90660
Residue:
202
Sequence:
MSERIASVERTTSETHISCTIDLDHIPGVTEQKINVSTGIGFLDHMFTALAKHGGMSLQLQCKGDLHIDDHHTAEDCALALGEAFKKALGERKGIKRYGYAYAPLDESLSRAVIDISSRPYFMCHLPFTREKVGDLSTEMVSHLLQSFAFAAGVTLHIDSIRGENNHHIAESAFKALALAIRMAISRTGGDDVPSTKGVLAL
  
Inhibitor
Name:
BDBM50079730
Synonyms:
CHEMBL416850 | [2-(4-Butyl-benzoylamino)-3-[1,2,4]triazol-1-yl-propyl]-phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C16H23N4O4P
Mol. Mass.:
366.352
SMILES:
CCCCc1ccc(cc1)C(=O)NC(Cn1cncn1)CP(O)(O)=O
Structure:
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