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Target
Imidazoleglycerol-phosphate dehydratase
Ligand
BDBM50079740
Substrate
n/a
Meas. Tech.
ChEMBL_90659 (CHEMBL700890)
IC50
920±n/a nM
Citation
 Schweitzer, BA; Loida, PJ; Thompson-Mize, RL; CaJacob, CA; Hegde, SG Design and synthesis of beta-carboxamido phosphonates as potent inhibitors of imidazole glycerol phosphate dehydratase. Bioorg Med Chem Lett 9:2053-8 (1999) [PubMed]  Article 
Target
Name:
Imidazoleglycerol-phosphate dehydratase
Synonyms:
HIS3 | HIS7_CRYNB | IGPD
Type:
PROTEIN
Mol. Mass.:
21976.83
Organism:
Cryptococcus neoformans
Description:
ChEMBL_90660
Residue:
202
Sequence:
MSERIASVERTTSETHISCTIDLDHIPGVTEQKINVSTGIGFLDHMFTALAKHGGMSLQLQCKGDLHIDDHHTAEDCALALGEAFKKALGERKGIKRYGYAYAPLDESLSRAVIDISSRPYFMCHLPFTREKVGDLSTEMVSHLLQSFAFAAGVTLHIDSIRGENNHHIAESAFKALALAIRMAISRTGGDDVPSTKGVLAL
  
Inhibitor
Name:
BDBM50079740
Synonyms:
CHEMBL62933 | [2-(2-Phenylsulfanyl-acetylamino)-3-[1,2,4]triazol-1-yl-propyl]-phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C13H17N4O4PS
Mol. Mass.:
356.337
SMILES:
OP(O)(=O)CC(Cn1cncn1)NC(=O)CSc1ccccc1
Structure:
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