Reaction Details Report a problem with these data
Target
Alpha-mannosidase
Ligand
BDBM50525021
Substrate
n/a
Meas. Tech.
ChEMBL_1895273 (CHEMBL4397308)
Ki
7000±n/a nM
Citation
 Rísquez-Cuadro, R; Matsumoto, R; Ortega-Caballero, F; Nanba, E; Higaki, K; García Fernández, JM; Ortiz Mellet, C Pharmacological Chaperones for the Treatment of ?-Mannosidosis. J Med Chem 62:5832-5843 (2019) [PubMed]  Article 
Target
Name:
Alpha-mannosidase
Synonyms:
Alpha-mannosidase | Alpha-mannosidase, heavy subunit | Alpha-mannosidase, light subunit | JBM | Jbalpha-man | MANA_CANEN
Type:
PROTEIN
Mol. Mass.:
108565.93
Organism:
Canavalia ensiformis
Description:
ChEMBL_109557
Residue:
959
Sequence:
MKYNTGAGTVPEQLNVHLVPHSHDDVGWLKTVDQYYVGSENYIQEACVENVLDSVVMSLQRDPNRKFVFGEMAFFHRWWLEQTPETKELKLVKAGQLEFVNGGWCMHDEATTHYIDMIDHTTLGHRFLQEQFNKIPRAGWQIDPFGHSAVQGYLLGAELGFDSVHFARIDYQDREKRKGEKSLEVVWRGSKTFGSSAQIFANAFPGHYGPPNGFNFEVRNNFVPLQDDPRLFDTNVEERVQNFLDAALTQAKLTRTNHLMWTMGDDFQYQYAESWFKQMDKLLHHVNKDGRVNALYSTPSLYTEAKNAANQTWPLKIDDYFPYADGRNAYWTGFYTSRMLSGYYLATRHSGFFAGKKSTKYHAFDLADALGIAQHHDAVSGTAKQHTTNDYAKRLALGASKAEAVVSSSLACLTSKQSADQCSAPASAFSQCHLFNISYCPPTESSLPDDKSLVVVVYNPLGWSRNEIVRIPVNDANLVVKDSSGNKLEVQYVEMDDVTANLRSFYVKYWSLFKASVPPLGWSTYFISEATGKGTRNALTLSQKGETLNIGPGDLKMSFSSLTGQLKRMYNSKTGVDLPIQQNYLWYESSEGDFSDYQASGAYLFRPNGQPPPHTVSRSSVTRVTRGPLVDEVHQKFNSWISQVTRLYKDKDHAEIEFTIGPIPTDDGVGKEVITRMTSTMATNKEFYTDSNGRDFLKRVRDYREDWPLEVTQPVAGNYYPLNLGLYTKDEKSEFSVLVDRATGGASIKDGEVELMLHRRTLRDDGRGVGEPLDEQVCMNKEYTCEGLTVRGNYYLSIHKPAGGSRWRRTTGQEIYSPMLLAFTQENMENWKSSHSTKAYAMDPNYSLPPSVALITLEELDDGLVLLRLAHLYEPSEDAEYSTLTKVELKKLFATQKLEELREVSLSANQEKSEMKKMKWSVEGDNEQEPQAVRGGPVSNADFVVELGPMEIRTFLLQF
  
Inhibitor
Name:
BDBM50525021
Synonyms:
CHEMBL4483772
Type:
Small organic molecule
Emp. Form.:
C7H12N2O5
Mol. Mass.:
204.1806
SMILES:
[H][C@]12COC(=O)N1[C@H](N)[C@@H](O)[C@@H](O)[C@@H]2O |r|
Structure:
Search PDB for entries with ligand similarity: