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Target
Integrase
Ligand
BDBM50079925
Substrate
n/a
Meas. Tech.
ChEMBL_90900 (CHEMBL699513)
IC50
58000±n/a nM
Citation
 Neamati, N; Turpin, JA; Winslow, HE; Christensen, JL; Williamson, K; Orr, A; Rice, WG; Pommier, Y; Garofalo, A; Brizzi, A; Campiani, G; Fiorini, I; Nacci, V Thiazolothiazepine inhibitors of HIV-1 integrase. J Med Chem 42:3334-41 (1999) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50079925
Synonyms:
6-Bromo-2,3-dihydro-1,9-dithia-3a-aza-benzo[f]azulene-4,10-dione | CHEMBL323255
Type:
Small organic molecule
Emp. Form.:
C11H8BrNO2S2
Mol. Mass.:
330.221
SMILES:
Brc1ccc2SC(=O)C3SCCN3C(=O)c2c1
Structure:
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