Reaction Details Report a problem with these data
Target
Bcl-2-like protein 2
Ligand
BDBM31802
Substrate
n/a
Meas. Tech.
ChEMBL_1896423 (CHEMBL4398458)
Ki
2100±n/a nM
Citation
 Yang, S; Mao, Y; Zhang, H; Xu, Y; An, J; Huang, Z The chemical biology of apoptosis: Revisited after 17 years. Eur J Med Chem 177:63-75 (2019) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 2
Synonyms:
Apoptosis regulator Bcl-W | B2CL2_HUMAN | BCL-W | BCL2L2 | BCLW | Bcl-2-like protein 2 | Bcl2-L-2 | KIAA0271
Type:
Protein
Mol. Mass.:
20742.61
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
193
Sequence:
MATPASAPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQEWMVAYLETQLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVALGALVTVGAFFASK
  
Inhibitor
Name:
BDBM31802
Synonyms:
Apogossypol | US9115061, Apogossypol
Type:
Small organic molecule
Emp. Form.:
C28H30O6
Mol. Mass.:
462.5342
SMILES:
CC(C)c1c(O)c(O)cc2c(O)c(c(C)cc12)-c1c(C)cc2c(C(C)C)c(O)c(O)cc2c1O |(-6.3,1.23,;-7.63,1.99,;-8.97,1.22,;-7.63,3.53,;-8.97,4.3,;-10.3,3.53,;-8.97,5.84,;-10.3,6.62,;-7.63,6.61,;-6.3,5.84,;-4.97,6.61,;-4.97,8.15,;-3.63,5.84,;-3.63,4.3,;-2.3,3.53,;-4.97,3.53,;-6.3,4.3,;-2.3,6.62,;-2.3,8.16,;-3.63,8.93,;-.97,8.93,;.37,8.16,;1.7,8.93,;1.7,10.47,;3.04,11.24,;.37,11.24,;3.04,8.16,;4.37,8.93,;3.04,6.62,;4.37,5.85,;1.7,5.85,;.37,6.62,;-.97,5.85,;-.97,4.31,)|
Structure:
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