Reaction Details Report a problem with these data
Target
Growth/differentiation factor 8
Ligand
BDBM50525413
Substrate
n/a
Meas. Tech.
ChEMBL_1896818 (CHEMBL4398853)
IC50
130±n/a nM
Citation
 Takayama, K; Asari, T; Saitoh, M; Nirasawa, K; Sasaki, E; Roppongi, Y; Nakamura, A; Saga, Y; Shimada, T; Ikeyama, H; Taguchi, A; Taniguchi, A; Negishi, Y; Hayashi, Y Chain-Shortened Myostatin Inhibitory Peptides Improve Grip Strength in Mice. ACS Med Chem Lett 10:985-990 (2019) [PubMed]  Article 
Target
Name:
Growth/differentiation factor 8
Synonyms:
GDF-8 | GDF8 | GDF8_HUMAN | Growth/differentiation factor 8 | MSTN | Myostatin
Type:
PROTEIN
Mol. Mass.:
42750.72
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109584
Residue:
375
Sequence:
MQKLQLCVYIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS
  
Inhibitor
Name:
BDBM50525413
Synonyms:
CHEMBL4448117
Type:
Small organic molecule
Emp. Form.:
C114H173N29O19
Mol. Mass.:
2253.7763
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)CC)[C@@H](C)CC)C1CCCCC1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C1CCCCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(N)=O |r|
Structure:
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