Reaction Details Report a problem with these data
Target
Phosphatidylcholine:ceramide cholinephosphotransferase 1
Ligand
BDBM50242188
Substrate
n/a
Meas. Tech.
ChEMBL_1897468 (CHEMBL4399503)
IC50
1500±n/a nM
Citation
Othman, MA; Yuyama, K; Murai, Y; Igarashi, Y; Mikami, D; Sivasothy, Y; Awang, K; Monde, K Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice. ACS Med Chem Lett 10:1154-1158 (2019) [PubMed] Article
More Info.:
Target
Name:
Phosphatidylcholine:ceramide cholinephosphotransferase 1
Synonyms:
MOB | Medulla oblongata-derived protein | Protein Mob | SGMS1 | SMS1 | SMS1_HUMAN | Sphingomyelin synthase 1 | TMEM23 | Transmembrane protein 23
Type:
PROTEIN
Mol. Mass.:
48630.99
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109868
Residue:
413
Sequence:
MKEVVYWSPKKVADWLLENAMPEYCEPLEHFTGQDLINLTQEDFKKPPLCRVSSDNGQRLLDMIETLKMEHHLEAHKNGHANGHLNIGVDIPTPDGSFSIKIKPNGMPNGYRKEMIKIPMPELERSQYPMEWGKTFLAFLYALSCFVLTTVMISVVHERVPPKEVQPPLPDTFFDHFNRVQWAFSICEINGMILVGLWLIQWLLLKYKSIISRRFFCIVGTLYLYRCITMYVTTLPVPGMHFNCSPKLFGDWEAQLRRIMKLIAGGGLSITGSHNMCGDYLYSGHTVMLTLTYLFIKEYSPRRLWWYHWICWLLSVVGIFCILLAHDHYTVDVVVAYYITTRLFWWYHTMANQQVLKEASQMNLLARVWWYRPFQYFEKNVQGIVPRSYHWPFPWPVVHLSRQVKYSRLVNDT
Inhibitor
Name:
BDBM50242188
Synonyms:
6-(8'Z-pentadecenyl)-salicylicacid | 6-[8'(Z)-pentadecenyl]salicylic acid | 6-[8(Z)-pentadecatrienyl]salicylic acid | 6-{8(Z)-pentadecenyl}salicylic acid | 6[8'(Z )-pentadecenyl]salicylic acid | Anacardic acid 8'Z-monoene | CHEMBL445177 | Ginkgolic acid C15:1 (1)
Type:
Small organic molecule
Emp. Form.:
C22H34O3
Mol. Mass.:
346.5036
SMILES:
CCCCCC\C=C/CCCCCCCc1cccc(O)c1C(O)=O