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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM24627
Substrate
n/a
Meas. Tech.
ChEMBL_1897720 (CHEMBL4399755)
Kd
360000±n/a nM
Citation
 Tsujino, H; Uno, T; Yamashita, T; Katsuda, M; Takada, K; Saiki, T; Maeda, S; Takagi, A; Masuda, S; Kawano, Y; Meguro, K; Akai, S Correlation of indoleamine-2,3-dioxigenase 1 inhibitory activity of 4,6-disubstituted indazole derivatives and their heme binding affinity. Bioorg Med Chem Lett 29:0 (2019) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM24627
Synonyms:
1H-indazole | Indazole, 5 | Indazole, 6
Type:
Small organic molecule
Emp. Form.:
C7H6N2
Mol. Mass.:
118.1359
SMILES:
c1n[nH]c2ccccc12
Structure:
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