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Target
cGMP-dependent protein kinase 1
Ligand
BDBM50182362
Substrate
n/a
Meas. Tech.
ChEMBL_1898233 (CHEMBL4400268)
IC50
<1000±n/a nM
Citation
 Large, JM; Birchall, K; Bouloc, NS; Merritt, AT; Smiljanic-Hurley, E; Tsagris, DJ; Wheldon, MC; Ansell, KH; Coombs, PJ; Kettleborough, CA; Whalley, D; Stewart, LB; Bowyer, PW; Baker, DA; Osborne, SA Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty. Bioorg Med Chem Lett 29:0 (2019) [PubMed]  Article 
Target
Name:
cGMP-dependent protein kinase 1
Synonyms:
GMP-dependent protein kinase I | KGP1_HUMAN | PRKG1 | PRKG1B | PRKGR1A | PRKGR1B | Protein Kinase G | cGMP-dependent protein kinase | cGMP-dependent protein kinase 1 | cGMP-dependent protein kinase 1 beta
Type:
Protein
Mol. Mass.:
76358.04
Organism:
Homo sapiens (Human)
Description:
Q13976
Residue:
671
Sequence:
MSELEEDFAKILMLKEERIKELEKRLSEKEEEIQELKRKLHKCQSVLPVPSTHIGPRTTRAQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF
  
Inhibitor
Name:
BDBM50182362
Synonyms:
4-(7-((dimethylamino)methyl)-2-(4-fluorophenyl)H-imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-amine | 4-(7-((dimethylamino)methyl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-amine | 4-[7-dimethylaminomethyl-2-(4-fluorophenyl)imidazo[1,2,-a]pyridin-3-yl]pyrimidin-2-ylamine | CHEMBL425949
Type:
Small organic molecule
Emp. Form.:
C20H19FN6
Mol. Mass.:
362.4035
SMILES:
CN(C)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(N)n1
Structure:
Search PDB for entries with ligand similarity: