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Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM13014
Substrate
n/a
Meas. Tech.
ChEMBL_152391 (CHEMBL765514)
Ki
220±n/a nM
Citation
 Grunewald, GL; Caldwell, TM; Li, Q; Slavica, M; Criscione, KR; Borchardt, RT; Wang, W Synthesis and biochemical evaluation of 3-fluoromethyl-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor. J Med Chem 42:3588-601 (1999) [PubMed]  Article 
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PNMT | PNMT_BOVIN | PNMTase
Type:
Enzyme
Mol. Mass.:
30916.97
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
283
Sequence:
MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGAFDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVREALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
  
Inhibitor
Name:
BDBM13014
Synonyms:
7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydrochloride | 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline | CHEMBL287837 | CHEMBL541797 | SKF 64139 | tetrahydroisoquinoline (THIQ) analogue
Type:
Small organic molecule
Emp. Form.:
C9H9Cl2N
Mol. Mass.:
202.08
SMILES:
Clc1ccc2CCNCc2c1Cl
Structure:
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