Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50080542
Substrate
n/a
Meas. Tech.
ChEMBL_28393 (CHEMBL636650)
EC50
34900±n/a nM
Citation
 van der Klein, PA; Kourounakis, AP; IJzerman, AP Allosteric modulation of the adenosine A(1) receptor. Synthesis and biological evaluation of novel 2-amino-3-benzoylthiophenes as allosteric enhancers of agonist binding. J Med Chem 42:3629-35 (1999) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
AA1R_RAT | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | Adenosine A1 receptor (A1) | Adenosine receptor | Adenosine receptors A1 | Adora1
Type:
Protein
Mol. Mass.:
36704.13
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
326
Sequence:
MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIDEDLPEEKAED
  
Inhibitor
Name:
BDBM50080542
Synonyms:
(2-Amino-4,5,6,7-tetrahydro-benzo[b]thiophen-3-yl)-p-tolyl-methanone | CHEMBL331504
Type:
Small organic molecule
Emp. Form.:
C16H17NOS
Mol. Mass.:
271.377
SMILES:
Cc1ccc(cc1)C(=O)c1c(N)sc2CCCCc12
Structure:
Search PDB for entries with ligand similarity: