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Target
Adenosine receptor A1
Ligand
BDBM50080545
Substrate
n/a
Meas. Tech.
ChEMBL_28393 (CHEMBL636650)
EC50
11300±n/a nM
Citation
 van der Klein, PA; Kourounakis, AP; IJzerman, AP Allosteric modulation of the adenosine A(1) receptor. Synthesis and biological evaluation of novel 2-amino-3-benzoylthiophenes as allosteric enhancers of agonist binding. J Med Chem 42:3629-35 (1999) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
AA1R_RAT | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | Adenosine A1 receptor (A1) | Adenosine receptor | Adenosine receptors A1 | Adora1
Type:
Protein
Mol. Mass.:
36704.13
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
326
Sequence:
MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIDEDLPEEKAED
  
Inhibitor
Name:
BDBM50080545
Synonyms:
(2-Amino-6-benzyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridin-3-yl)-(4-chloro-phenyl)-methanone | (2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-3-yl)(4-chlorophenyl)methanone | CHEMBL303124 | PD-117915
Type:
Small organic molecule
Emp. Form.:
C21H19ClN2OS
Mol. Mass.:
382.906
SMILES:
Nc1sc2CN(Cc3ccccc3)CCc2c1C(=O)c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: