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Target
D(4) dopamine receptor
Ligand
BDBM50080809
Substrate
n/a
Meas. Tech.
ChEMBL_61011 (CHEMBL675016)
Ki
4.4±n/a nM
Citation
 Kesten, SR; Heffner, TG; Johnson, SJ; Pugsley, TA; Wright, JL; Wise, LD Design, synthesis, and evaluation of chromen-2-ones as potent and selective human dopamine D4 antagonists. J Med Chem 42:3718-25 (1999) [PubMed]  Article 
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
  
Inhibitor
Name:
BDBM50080809
Synonyms:
7-(4-Phenyl-3,6-dihydro-2H-pyridin-1-ylmethyl)-chromen-2-one | CHEMBL332001
Type:
Small organic molecule
Emp. Form.:
C21H19NO2
Mol. Mass.:
317.3811
SMILES:
O=c1ccc2ccc(CN3CCC(=CC3)c3ccccc3)cc2o1 |c:12|
Structure:
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