Reaction Details Report a problem with these data
Target
Hepatic triacylglycerol lipase
Ligand
BDBM50525868
Substrate
n/a
Meas. Tech.
ChEMBL_1898348 (CHEMBL4400383)
IC50
170±n/a nM
Citation
 Meng, W; Adam, LP; Behnia, K; Zhao, L; Yang, R; Kopcho, LM; Locke, GA; Taylor, DS; Yin, X; Wexler, RR; Finlay, H Benzothiazole-based compounds as potent endothelial lipase inhibitors. Bioorg Med Chem Lett 29:0 (2019) [PubMed]  Article 
Target
Name:
Hepatic triacylglycerol lipase
Synonyms:
HL | HTGL | Hepatic Lipase (HL) | Hepatic lipase | Hepatic triacylglycerol lipase | LIPC | LIPC_HUMAN | Lipase member C
Type:
Protein
Mol. Mass.:
55938.55
Organism:
Homo sapiens (Human)
Description:
P11150
Residue:
499
Sequence:
MDTSPLCFSILLVLCIFIQSSALGQSLKPEPFGRRAQAVETNKTLHEMKTRFLLFGETNQGCQIRINHPDTLQECGFNSSLPLVMIIHGWSVDGVLENWIWQMVAALKSQPAQPVNVGLVDWITLAHDHYTIAVRNTRLVGKEVAALLRWLEESVQLSRSHVHLIGYSLGAHVSGFAGSSIGGTHKIGRITGLDAAGPLFEGSAPSNRLSPDDANFVDAIHTFTREHMGLSVGIKQPIGHYDFYPNGGSFQPGCHFLELYRHIAQHGFNAITQTIKCSHERSVHLFIDSLLHAGTQSMAYPCGDMNSFSQGLCLSCKKGRCNTLGYHVRQEPRSKSKRLFLVTRAQSPFKVYHYQFKIQFINQTETPIQTTFTMSLLGTKEKMQKIPITLGKGIASNKTYSFLITLDVDIGELIMIKFKWENSAVWANVWDTVQTIIPWSTGPRHSGLVLKTIRVKAGETQQRMTFCSENTDDLLLRPTQEKIFVKCEIKSKTSKRKIR
  
Inhibitor
Name:
BDBM50525868
Synonyms:
CHEMBL4557646
Type:
Small organic molecule
Emp. Form.:
C25H23N5O3S
Mol. Mass.:
473.547
SMILES:
O=C(CNC(=O)C(C#N)c1nc2ccc(cc2s1)-c1ccc(cc1)C(=O)N1CCC1)NC1CC1
Structure:
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